Publication

New Review Publication on Insect Hormone Quantification and Manipulation

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We are pleased to highlight a new collaborative review published in Current Opinion in Insect Science, co-authored with colleagues Fernando G. Noriega, Guy Bloch, Martin Moos, Petr Šimek, and Marek Jindra. The article, “Approaches to quantify and manipulate insect hormone signals,” provides an up-to-date overview of state-of-the-art methods used to study the key lipidic insect … Read more

New Collaborative Publication with the Algatech Centre: Cyanophycinase as a Key Regulator of Heterotrophy in Cyanobacteria

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We are proud to share a new joint publication arising from our long-term collaboration with Roman Sobotka’s research group at the Algatech Centre (Institute of Microbiology, CAS). The study reveals a previously unknown role of cyanophycinase (CphB) in enabling heterotrophic growth in the model cyanobacterium Synechocystis sp. PCC 6803.

The Algatech team discovered that deleting the cphB gene completely blocks light-activated heterotrophic growth. To uncover the metabolic basis of this phenotype, our laboratory contributed targeted LC-HRMS metabolomics, which showed that CphB is essential for activating arginine biosynthesis and for maintaining a balanced carbon–nitrogen and nucleotide metabolism during the transition from photosynthesis to heterotrophy.

Together, the teams demonstrated that CphB interacts with the key arginine-pathway enzyme ArgD and stimulates cyanophycin degradation, revealing a tightly coordinated metabolic system unique to cyanobacteria.

Adenosine is a sensor of a balance between cell activity and nutrient supply

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How does a cell measure its current activity in order to ask its neighborhood for an adequate supply of nutrients? Pavla Nedbalova and Tomas Dolezal’s team from the Faculty of Science, University of South Bohemia, have found a possible mechanism where adenosin could be at the center. The discovery, The discovery, in which scientists from … Read more

New Publication: Metabolomic Signatures of Cold Adaptation Across 43 Drosophila Specie

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We are pleased to highlight a new collaborative publication led by Vladimír Koštál’s group (Institute of Entomology, BC CAS), with major contributions from Martin Moos and our metabolomics team. The study provides the most comprehensive metabolomic comparison to date of cold adaptation across 43 Drosophila species, spanning tropical to boreal climates. The article is published in Journal of Experimental … Read more