Projects

New approaches in targeted metabolomic analysis of unstable metabolites with oxo group: labeling with quaternary ammonium and stable isotopes

by

Czech Science Foundation, No. 23-06600S (2023-2025) This project addresses a fundamental analytical limitation of current LC–MS–based metabolomics: the insufficient detectability of chemically unstable metabolites containing aldehyde or keto (oxo) groups. Many biologically essential oxo-metabolites play central roles in energy metabolism, redox balance, and cellular signaling, yet remain analytically inaccessible due to rapid degradation, poor ionization efficiency, … Read more

New bioanalytical tools for complex analysis of metabolism and personalized clinical diagnostics.

by

Czech Ministry of Education, Operation program Jan Amos Komensky, project reg. no. CZ.02.01.01/00/23_021/0008906 (BudDiag), co-funded by the European Union (2024-2028) Research partners: Hospital České Budějovice; AnyCare s.r.o.; Chromservis s.r.o.; Univerity of South Bohemia, Faculty of Science The BudDiag project focuses on the development and clinical translation of advanced bioanalytical tools for comprehensive metabolomic analysis, with the … Read more

Postcopulatory sexual selection: mechanisms and evolutionary consequences in sexually promiscuous passerines.

by

Czech Science Foundation No. 25-17505S (2025-2027) Research partners: Tomáš Albrecht – Institute of Vertebrate Biology, CAS; Radka Reifová – Faculty of Science, Charles University This project addresses one of the central paradigm shifts in evolutionary biology: the recognition that mate choice and sexual selection can continue after copulation. In many passerine birds, high levels of sexual … Read more

Bioanalytical kit for quantitative analysis of lipid fatty acids

by

Sigma DC1 -TQ11000026 – LipoQuant kit (2025-2026) Research partners: Chromservis s.r.o. This project, funded by the TAČR SIGMA – Proof of Concept programme, is focused on the development of a novel bioanalytical kit (LipoQuant Kit) for the quantitative analysis of lipid-bound fatty acids in complex biological matrices. Lipid-bound fatty acids represent a major fraction of cellular lipids and play a … Read more

CODE – Complex Omics Digital Engine

by

OP TAK – Aplikace II (2026–2027) Research partners: Institute of Applied Biotechnologies a.s.;AnyCare s.r.o. This project develops a next-generation digital infrastructure for secure storage, management, integration, and analysis of large-scale multi-omics data (genomic, transcriptomic, proteomic, metabolomic, lipidomic). The CODE platform supports data-intensive life sciences and precision medicine by providing a robust, interoperable, and scalable environment … Read more

Metabolic Energy Substrates in Avian Blood.

by

Czech Science Foundation, No. 26-22858S (2026-2028) Research partners: Oldřich Tomášek – Institute of Vertebrate Biology, Czech Academy of Sciences; Tomáš Albrecht – Faculty of Science, Charles University This project, funded by the Czech Science Foundation (GAČR), investigates the ecological and evolutionary significance of circulating metabolic energy substrates in birds, with a particular focus on blood glucose and free fatty acids (FFAs). These … Read more

Fatty Acid–Driven Immune Modulation in Antifungal Host Defence

by

Czech Science Foundation, No. 26-19900L (2026-2028) Research partners: Agata Kaczmarek; Witold Stefański Institute of Parasitology; Warsaw, PL This Polish–Czech collaborative project investigates how dietary fatty acids modulate immune responses to fungal infections, with a particular focus on infections caused by the opportunistic pathogen Conidiobolus coronatus. Fungal infections pose an increasing threat to human and animal health, exacerbated … Read more