Sasa Jegorov

Fatty Acid–Driven Immune Modulation in Antifungal Host Defence

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This Polish–Czech collaborative project investigates how dietary fatty acids modulate immune responses to fungal infections, with a particular focus on infections caused by the opportunistic pathogen Conidiobolus coronatus. Fungal infections pose an increasing threat to human and animal health, exacerbated by climate change, global mobility, and the growing prevalence of antifungal resistance. Identifying alternative strategies that strengthen … Read more

New International Grant on Nutritional Immunology and Fungal Infections

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We are pleased to announce a new Polish–Czech collaborative research grant focused on understanding how dietary fatty acids modulate immune responses to fungal infections. The project uses the wax moth Galleria mellonella as a well-established alternative infection model with strong relevance to mammalian innate immunity. The main goal of the project is to determine whether fatty acid supplementation can enhance host … Read more

New GAČR Project: Metabolic Energy Substrates in Avian Blood

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Our laboratory is a co-investigator in the newly funded Czech Science Foundation project 26-22858S, led by MVDr. Oldřich Tomášek, Ph.D. from the Institute of Vertebrate Biology, Czech Academy of Sciences (IVB). The project team also includes collaborators from the Faculty of Science, Charles University. The project, “Metabolic energy substrates in avian blood: sources of variation, … Read more

New Review Publication on Insect Hormone Quantification and Manipulation

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We are pleased to highlight a new collaborative review published in Current Opinion in Insect Science, co-authored with colleagues Fernando G. Noriega, Guy Bloch, Martin Moos, Petr Šimek, and Marek Jindra. The article, “Approaches to quantify and manipulate insect hormone signals,” provides an up-to-date overview of state-of-the-art methods used to study the key lipidic insect … Read more

New Collaborative Publication with the Algatech Centre: Cyanophycinase as a Key Regulator of Heterotrophy in Cyanobacteria

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We are proud to share a new joint publication arising from our long-term collaboration with Roman Sobotka’s research group at the Algatech Centre (Institute of Microbiology, CAS). The study reveals a previously unknown role of cyanophycinase (CphB) in enabling heterotrophic growth in the model cyanobacterium Synechocystis sp. PCC 6803.

The Algatech team discovered that deleting the cphB gene completely blocks light-activated heterotrophic growth. To uncover the metabolic basis of this phenotype, our laboratory contributed targeted LC-HRMS metabolomics, which showed that CphB is essential for activating arginine biosynthesis and for maintaining a balanced carbon–nitrogen and nucleotide metabolism during the transition from photosynthesis to heterotrophy.

Together, the teams demonstrated that CphB interacts with the key arginine-pathway enzyme ArgD and stimulates cyanophycin degradation, revealing a tightly coordinated metabolic system unique to cyanobacteria.

We have organized 13th Conference of Czech Mass Spectrometry

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195 participants registered, with 23 lectures, 14 short talks, and 55 posters presented. The event was held under the main organizational lead of Martin Moos. Prominent scientific figures and dozens of experts in mass spectrometry and proteomics arrived in České Budějovice to attend the 13th Conference of the Czech Society for Mass Spectrometry and the … Read more

Professor Alexander Makarov visited our laboratory

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Professor Alexander Makarov visited our laboratory as part of the Conference of Czech Mass Spectrometry. During his visit, Professor Makarov was introduced to our ongoing research activities and the key instrumentation used in our projects. Members of our team had the opportunity to discuss current challenges in mass spectrometry and future directions in the field. … Read more

Adenosine is a sensor of a balance between cell activity and nutrient supply

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How does a cell measure its current activity in order to ask its neighborhood for an adequate supply of nutrients? Pavla Nedbalova and Tomas Dolezal’s team from the Faculty of Science, University of South Bohemia, have found a possible mechanism where adenosin could be at the center. The discovery, The discovery, in which scientists from … Read more

New Publication: Metabolomic Signatures of Cold Adaptation Across 43 Drosophila Specie

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We are pleased to highlight a new collaborative publication led by Vladimír Koštál’s group (Institute of Entomology, BC CAS), with major contributions from Martin Moos and our metabolomics team. The study provides the most comprehensive metabolomic comparison to date of cold adaptation across 43 Drosophila species, spanning tropical to boreal climates. The article is published in Journal of Experimental … Read more