Sasa Jegorov

New approaches in targeted metabolomic analysis of unstable metabolites with oxo group: labeling with quaternary ammonium and stable isotopes

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Czech Science Foundation, No. 23-06600S (2023-2025) This project addresses a fundamental analytical limitation of current LC–MS–based metabolomics: the insufficient detectability of chemically unstable metabolites containing aldehyde or keto (oxo) groups. Many biologically essential oxo-metabolites play central roles in energy metabolism, redox balance, and cellular signaling, yet remain analytically inaccessible due to rapid degradation, poor ionization efficiency, … Read more

New bioanalytical tools for complex analysis of metabolism and personalized clinical diagnostics.

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Czech Ministry of Education, Operation program Jan Amos Komensky, project reg. no. CZ.02.01.01/00/23_021/0008906 (BudDiag), co-funded by the European Union (2024-2028) Research partners: Hospital České Budějovice; AnyCare s.r.o.; Chromservis s.r.o.; Univerity of South Bohemia, Faculty of Science The BudDiag project focuses on the development and clinical translation of advanced bioanalytical tools for comprehensive metabolomic analysis, with the … Read more

Postcopulatory sexual selection: mechanisms and evolutionary consequences in sexually promiscuous passerines.

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Czech Science Foundation No. 25-17505S (2025-2027) Research partners: Tomáš Albrecht – Institute of Vertebrate Biology, CAS; Radka Reifová – Faculty of Science, Charles University This project addresses one of the central paradigm shifts in evolutionary biology: the recognition that mate choice and sexual selection can continue after copulation. In many passerine birds, high levels of sexual … Read more

Bioanalytical kit for quantitative analysis of lipid fatty acids

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Sigma DC1 -TQ11000026 – LipoQuant kit (2025-2026) Research partners: Chromservis s.r.o. This project, funded by the TAČR SIGMA – Proof of Concept programme, is focused on the development of a novel bioanalytical kit (LipoQuant Kit) for the quantitative analysis of lipid-bound fatty acids in complex biological matrices. Lipid-bound fatty acids represent a major fraction of cellular lipids and play a … Read more

CODE – Complex Omics Digital Engine

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OP TAK – Aplikace II (2026–2027) Research partners: Institute of Applied Biotechnologies a.s.;AnyCare s.r.o. This project develops a next-generation digital infrastructure for secure storage, management, integration, and analysis of large-scale multi-omics data (genomic, transcriptomic, proteomic, metabolomic, lipidomic). The CODE platform supports data-intensive life sciences and precision medicine by providing a robust, interoperable, and scalable environment … Read more

Metabolic Energy Substrates in Avian Blood.

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Czech Science Foundation, No. 26-22858S (2026-2028) Research partners: Oldřich Tomášek – Institute of Vertebrate Biology, Czech Academy of Sciences; Tomáš Albrecht – Faculty of Science, Charles University This project, funded by the Czech Science Foundation (GAČR), investigates the ecological and evolutionary significance of circulating metabolic energy substrates in birds, with a particular focus on blood glucose and free fatty acids (FFAs). These … Read more

Johannes Overgaard

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Aarhus University; Department of Biology – Zoophysiology; DK Our collaboration with Prof. Johannes Overgaard focuses on the physiological and metabolic mechanisms underlying insect cold tolerance, seasonal acclimation, and thermal adaptation. By combining comparative physiology, experimental ecology, and metabolomics, we investigate how insects adjust their metabolism and cellular function in response to low-temperature stress across diverse … Read more

Fernando Noriega

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Florida International University; College of Arts, Sciences & Education; Florida, US Our collaboration with Prof. Fernando Noriega focuses on the molecular and hormonal regulation of insect reproduction and development, with a particular emphasis on juvenile hormone and ecdysteroid signaling pathways. Together, we combine advanced bioanalytical mass-spectrometry-based approaches with molecular biology and functional genomics to quantify, … Read more

Brian Sedio

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The University of Texas at Austin; Texas, US Our collaboration with Dr. Brian Sedio focuses on plant chemical diversity and induced defense responses, particularly the metabolic variation underlying plant–herbivore interactions. By integrating chemical ecology, metabolomics, and evolutionary perspectives, we investigate how plants modulate both volatile and non-volatile metabolites in response to herbivory across related species. … Read more

Simon Segar

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Harper Adams University; Agriculture and Environment; UK Our collaboration with Dr. Simon T. Segar focuses on tropical plant–insect interactions and community-level drivers of herbivory, with an emphasis on how plant defensive traits shape insect herbivore diversity and structure. By combining field-based ecological research, chemical ecology, and metabolomic analyses, we investigate multitrophic interactions across environmental gradients … Read more